Synthetic Biology and Genetic Modifications of Cells

Synthetic Biology is one of the emerging field of research that can be broadly described as the design and construction of novel artificial biological pathways, organisms or devices or the redesigning of existing natural biological systems. Genome editing  with engineered nucleases is a type of genetic engineering in which DNA is either inserted, replaced or deleted in the genome of an organism using engineered nucleases or “molecular scissors”. These nucleases hence create site specific double stranded breaks (DSBs) at desired locations in the genome. The induced double stranded breaks are repaired through non homologous end- joining (NHEJ) or homologous recombination (HR), thus resulting in targeted mutations (edits”). Scientists now a days use various engineered nucleases in order to bring desired changes in the human genome.   

  • Synthetic biology applications
  • Gene editing tools
  • Genetic engineering
  • Genetic modification of human embryonic stem cells
  • Genetically modified immune cells control HIV long-term
  • Genetically modified T cells in cancer therapy

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