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Sarah J Freemantle

University of Illinois at Urbana-Champaign, USA

Biography

Sarah Freemantle, Ph.D. is a new faculty member in the Department of Comparative Bioscience at the University of Illinois College of Veterinary Medicine.  She received her Ph.D. degree from the University of Newcastle-upon-Tyne, England where she examined resistance to antimetabolite-based chemotherapy agents. She continued her work on folate-based chemotherapeutics in her post-doctoral studies at the Medical College of Virginia before taking a position at Dartmouth Medical School in 1998.  At Dartmouth she worked on genes involved in chemoprevention and developed several mouse models for lung cancer and knockouts of key genes. More recent work has examined genes involved in chemotherapy response and chemoprevention which include the G0S2 gene.  

Abstract

Abstract : G0S2 represses PI3K/AKT/mTOR signaling and increases sensitivity to PI3K/mTOR pathway inhibitors in estrogen receptor-positive breast cancer cells